Guardant Health, Inc. (GH)
Fair ValueFundamental
47
Price
$178.36
Market Cap
$23.94B
Part 1 · What the company is worth
Overview
Guardant Health, Inc., a precision oncology company, provides blood and tissue tests, and data sets in the United States and internationally. The company offers Guardant360 CDx test, a liquid biopsy test for tumor mutation profiling; Guardant360 Liquid test, which measures 740+ genes and supports all guideline-recommended biomarkers; Guardant Reveal test, a blood test that utilizes circulating tumor DNA to detect cancer at the molecular level; and Guardant360 Tissue test, a molecular profiling test for tumor tissue that provides genomic, transcriptomic, and epigenomic insights. It also provides Shield blood test for colorectal cancer screening in adults. In addition, the company offers GuardantINFINITY test that provides insights into the complexities of tumor molecular profiles and immune response to advance cancer research and therapy development; GuardantOMNI test covers 500 genes, including genes associated with homologous recombination repair deficiency and biomarkers for immuno-oncology applications; GuardantINFORM, which provides longitudinal biological insight into tumor evolution alongside longitudinal clinical outcomes; and GuardantConnect, an integrated software-based solution designed for clinical and biopharmaceutical customers to connect patients tested with assays with actionable alterations with potentially relevant clinical studies. Further, it provides Smart Platform, which delivers multiomic insights leveraging genomic, epigenomic, and RNA-based data that are scalable from research to the clinic. Additionally, the company offers development services, including companion diagnostic development and regulatory approval, clinical study setup, monitoring and maintenance, testing development and support, technologies licensing, and kit fulfillment and delivery of Shield screening tests. It has a strategic collaboration with Nuvalent, Inc. for oncology drug development. The company was incorporated in 2011 and is headquartered in Palo Alto, California.
No editorial profile for this company yet
Direct competitors
Who this company fights with for the same customers
Generated on September 18, 2026 with claude-haiku-4-5 — shared with all users
Natera's Signatera is the market-leading blood test for molecular residual disease after cancer surgery, competing directly with Guardant Reveal for the same oncologists and the same post-treatment monitoring reimbursement.
Tempus sells the xF+ liquid biopsy panel and tissue profiling to the same oncology practices, competing with Guardant on both therapy selection and residual disease testing.
A wholly owned Roche subsidiary whose FoundationOne Liquid CDx and FoundationOne CDx panels are the closest rivals to Guardant360 for comprehensive genomic profiling used to pick a cancer therapy.
Acquired by Abbott in March 2026 and no longer separately listed, Exact Sciences sells Cologuard and its own blood-based colorectal screening test to the same primary-care physicians Guardant targets with Shield.
Caris competes for the same oncologists' test orders with whole-exome tissue profiling and its Caris Assure blood platform, covering therapy selection and residual disease alongside Guardant.
GRAIL's Galleri is the leading multi-cancer blood screening test, competing with Guardant's Shield franchise for the same asymptomatic screening population and employer or health-system contracts.
Balance Sheet & Liquidity
Revenue
$1.18B
Trailing 12 months (through 6/30/2026)
Net Income
$-453M
Trailing 12 months (through 6/30/2026)
Free Cash Flow
$-233M
Total Equity
$-99M
Total Liabilities
$2.11B
Current Ratio
4.03
Interest Coverage
97.65
Debt/EBITDA
-
Earnings Per Share
Revenue & Net Income
Free Cash Flow
Income Breakdown
Historical statement
Margins over time
Debt over time
How heavy the debt is
Growth grid
Growth — Revenue
Fair Value Estimation
Fair Value
$197.04
Current Price
$178.36
Margin of Safety
+9.5%
Fair Value Range
$187.19 - $206.89
Spread across the valuation methods used, not a statistically calibrated confidence interval.
Estimation Methods
Valuation Metrics
P/E Ratio
-
ROE
419.2%
P/B Ratio
-
P/FCF
-
Gross Margin
65.0%
ROIC
-23.6%
Profitability Radar
Value Creation (Economic Moat)
ROIC
-23.6%
WACC
13.1%
ROIC − WACC
-36.7 pp
ROIC is below the cost of capital — the company is destroying value for every dollar invested.
Fundamental Analysis Criteria
Passed (11)
- EPS shows upward trend
- Price CAGR 21.31%
- Gross Margin 65.0%
- Current Ratio
- Interest Coverage
- Low reliance on intangibles
- Revenue Growth 5Y 27.9%
- Analyst Consensus 91% Buy
- Share Dilution 2.3%
- Net Margin Trend -38.3% vs -49.9%
- Piotroski F-Score 5/9
Failed (7)
- ROIC -23.6%
- Operating Margin -39.7%
- Positive Free Cash Flow
- Return on Tangible Assets
- DCF valuation (Unknown)
- ROE -246.6%
- Earnings Surprise avg -7.2%
Unavailable (9)
- P/FCF NaN
- P/B Ratio NaN
- Dividend Payout NaN%
- Debt/Equity ratio
- CapEx intensity
- Debt/EBITDA
- Price below Graham Number
- PEG Ratio (need PE > 0 and growth > 0)
- Earnings Quality (OCF/Net Income)
Piotroski F-Score
Mixed signals: some areas need attention
Earnings Quality
Low quality: investigate accounting
Share Dilution
Issuing new shares, diluting ownership
Institutional Holdings
Governance
Executive Team
| Name | Title | Age |
|---|---|---|
| Dr. Helmy Eltoukhy Ph.D. | Co-Founder, Co-CEO & Chairman | 46 |
| Dr. AmirAli Talasaz Ph.D. | Co-CEO & Director | 45 |
| Mr. Michael Bell | Chief Financial Officer | 56 |
| Dr. Darya Chudova | Chief Technology Officer | 51 |
| Mr. John G. Saia J.D. | Chief Legal Officer & Corporate Secretary | 52 |
| Mr. Andy Ament | Senior Vice President of Operations | - |
| Mr. Kumud Kalia | Chief Information Officer | 59 |
| Zarak Khurshid | Vice President of Investor Relations | - |
| Ms. Gulshan Shaver J.D. | Senior VP of Legal Affairs & Chief Compliance Officer | - |
| Ms. Jennifer Higgins | Senior Vice President of Public Affairs | - |
Audit Risk
1
Board Risk
7
Compensation Risk
7
Shareholder Rights Risk
8
Part 2 · The price and when to enter
This part won't tell you whether the company is worth owning: it helps you choose when to buy it, once the fundamentals have convinced you. Inside: technical analysis, potential, historical drawdowns, gamma exposure.
Documents
- View document
Annual Report (10-K)
A yearly overview of the business, its financial results, and the risks it faces.
Filed on 2026-02-19
- View document
Quarterly Report (10-Q)
A snapshot of financial performance for the most recent three-month period.
Filed on 2026-07-30
- View document
Current Report (8-K)
An announcement of a major event, such as a leadership change or big news.
Filed on 2026-07-30
via SEC EDGAR
Income History
via SEC EDGAR
Latest News
Recent headlines for GH, sourced from Markets Gazette.
- 5/20/2026POSITIVEGuardant Health Secures FDA Approval For Expanded Liquid Biopsy Test
Guardant Health has received FDA approval for an expanded use of its Guardant360 Liquid CDx test. This blood-based cancer profiling tool now offers broader diagnostic capabilities, a significant step forward in non-invasive oncology diagnostics. The expanded approval is expected to enhance the test's utility for a wider range of cancer patients and treatment decisions. For investors, this regulatory milestone signifies strong product development and market potential, potentially leading to increased adoption and revenue growth for Guardant Health.
via Markets Gazette